New Investigator Grant: Dr. Jin Hyung Lee, Stanford

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We recently awarded a New Investigator Grant to Jin Hyung Lee, Ph.D., Assistant Professor, Neurology & Neurological Sciences and Bioengineering for her study “Direct Network Visualization of Alzheimer’s Drug Efficacy Using optogenetic functional MRI (ofMRI).”

Magnetic resonance imaging (MRI) is used in medical clinics to noninvasively image brain structure in living people. A version of MRI, functional MRI (fMRI), can be used to image brain activity by measuring blood flow and oxygen utilization to active brain regions.

Recently, scientists have developed another variation of fMRI known as optogenetic functional MRI (ofMRI). With ofMRI, researchers use light to activate nerve cells in a specific part of the brain, then image the brain to determine how activation spreads to other brain regions. At this time, ofMRI is used only in animal models because it requires surgical treatment of the brain to allow nerve cells to be activated by a pulse of light.

With this grant, Dr. Lee will look at using ofMRI as a way to test the effectiveness of drugs for treatment of animal models with Alzheimer’s-like disease. The technique may accelerate the development of drugs to treat Alzheimer’s disease.

For more about the Alzheimer’s Association research grants program, visit www.alz.org/research.

Helpful information related to this story

Alzheimer’s Association Research Center

More about Dr. Lee 

More about Dr. Lee’s Alzheimer’s Association-funded study

More blogs by Dr. Edgerly

1 Response

  1. Norm burns says:

    Dear dr lee.as a partner of a patient with vascular dementhia post stroke
    We welcome your research if you need another patient to do a trial study
    With please let us be. Of help .We are retired and will come down to Stanford.
    415-7718452 Or 415-519-6484

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